New taxonomic classification of non-skeletal rare congenital disorders with impact on bone physiology
Thanks to major progress in the understanding and management of rare congenital diseases and syndromes, many patients with these rare disorders are now living longer lives. With this progress it has become apparent that many non-skeletal rare diseases have an impact on bone mass, bone quality and/or bone metabolism, with potentially severe repercussions for quality of life in adults.
The new paper Bone fragility in patients affected by congenital diseases non skeletal in origin , published in
Orphanet Journal of Rare Diseases by the International Osteoporosis Foundation (IOF) Skeletal Rare Diseases Working Group (SRDWG), provides a first taxonomic classification of selected non-skeletal rare congenital disorders with an impact on bone physiology on the basis of phenotypes. The diseases have been described according to the systemic disease; genetic defect; pathophysiology of bone
Researchers study the behavior of regulatory T cells to understand periodontal disease
In diseases characterized by bone loss -such as periodontitis, rheumatoid arthritis, and osteoporosis- there is a lot that scientists still don t understand. What is the role of the immune response in the process? What happens to the regulatory mechanisms that protect bone?
In a paper published recently in
Scientific Reports, researchers from the Forsyth Institute and the Universidad de Chile describe a mechanism that unlocks a piece of the puzzle. Looking at periodontal disease in a mouse model, scientists found that a specific type of T cell, known as regulatory T cells, start behaving in unexpected ways. These cells lose their ability to regulate bone loss and instead begin promoting inflammation.
Moorooduc show strength, Hastings flop, Seaford pull off a hard-fought win
Picture: Craig Barrett
MOOROODUC have started the year on the right foot with a hard-fought win over Somerville.
Choosing to bat first, Moorooduc set their opponents a difficult target of 222 to chase down.
Opener Brenton Alp got the run chase off to a good start, scoring 60 runs. Number four batsman Bradley McDonald also contributed some runs to the scoreboard with a knock of 42.
Somerville took the game right down to the wire, but couldn’t get over the line. At the end of their forty overs they were at 9/215, seven runs short of a result and one wicket short of a win.
To build better vaccines, scientists want to know more about how our bodies make adequate numbers of effective, durable antibodies against the influenza virus.
Researchers discover many genetic markers related to bone mineral accrual
A multidisciplinary team of researchers led by Children s Hospital of Philadelphia (CHOP) has discovered several genetic markers associated with bone mineral accrual, which could ultimately help identify causes of eventual osteoporosis earlier in life through genetic testing. The findings, which were made possible by following a group of children over several years, were published online by the journal
Genome Biology.
Osteoporosis is widely considered a disease of old age. However, the accrual of bone density early in life is critical for achieving optimal bone mass in adulthood and influences bone health throughout a person s life. While studies have looked at genetic markers associated with bone health in adulthood, very few have been performed in children during the most critical period of bone growth.